PUBLICATIONS
2019
Yue, J., Lau, T.C.K., Griffith, J.F., Xu, J., Xiao, F., Shi, L., Wang, D., Wong, P.C.H., Li, E.K., Tam, L.P., Li, M., Li, T.K., Mak, W.Y., Hung, V., Qin, L., Tam, L.S. “Circulating miR-99b-5p as a novel predictor of erosion progression on high-resolution peripheral quantitative computed tomography in early rheumatoid arthritis: A prospective cohort study” International Journal of Rheumatic Diseases, Epub ahead of print (2019)
Law, C.O.K., Huang, C., Pan, Q., Lee, J., Hao, Q., Chan, T.F., Lo, N.W.S., Ang, I.L., Koon, A., Ip, M., Chan, H.Y.E., Lau, T.C.K. “A small RNA transforms the multidrug resistance of Pseudomonas aeruginosa to drug-susceptibility” Molecular Therapy-Nucleic Acids, Vol. 16, p. 218 (2019)
Long, Y., Sou, W.H., Yung, K.W.Y., Liu. H., Wan, S.W.C., Li, Q., Zeng, C., Law, C.O.K., Chan, G.H.C., Lau. T.C.K., Ngo, J.C.K. “Distinct mechanisms govern the phosphorylation of different SR protein splicing factors” Journal of Biological Chemistry, Vol. 294, p. 1312 (2019)
Chu, T., Weng, X., Law, C.O.K., Kong, H.K., Lau, J., Li, S,, Pham, H.Q., Wang, R., Zhang, L., Kao, R.Y.T., Lau, K.F., Ngo, J.C.K., Lau, T.C.K. “The ribosomal maturation factor P from Mycobacterium smegmatis facilitates the ribosomal biogenesis by binding to the small ribosomal protein S12” Journal of Biological Chemistry, Vol. 294, p. 372 (2019)
2018
Kong, H.K., Pan, Q., Lo, W.U., Liu, X., Law, C.O.K., Chan, T.F., Ho, P.L., Lau, T.C.K. “Fine-tuning carbapenem resistance by reducing porin permeability of bacteria activated in the selection process of conjugation” Scientific Reports, Vol. 8, p. 15248 (2018)
Pan, Q., Law, C.O.K., Yung, M.M.H., Han, K.C., Pon, Y.L., Lau, T.C.K. “Novel RNA aptamers targeting gastrointestinal cancer biomarkers CEA, CA50 and CA72-4 with superior affinity and specificity” PLoS One, Vol. 13, e0198980 (2018)
Xu, S., Webb, S.E., Lau, T.C.K., Cheng, S.H. “Matrix metalloproteinases (MMPs) mediate leukocyte recruitment during the inflammatory phase of zebrafish heart regeneration” Scientific Reports, Vol. 8, p. 7199 (2018)
Kong, H.K., Liu, X., Lo, W.U., Pan, Q., Law, C.O.K., Chan, T.F., Ho, P.L., Lau, T.C.K. “Identification of Plasmid-Encoded sRNAs in a blaNDM-1-Harboring Multidrug-Resistance Plasmid pNDM-HK in Enterobacteriaceae” Frontier of Microbiology, Vol. 9, p. 532 (2018)
Qin, H., Lo, N.W., Loo, J.F., Lin, X., Yim, A.K., Tsui, S.K., Lau, T.C.K., Ip, M., Chan, T.F. “Comparative transcriptomics of multidrug-resistant Acinetobacter baumannii in response to antibiotic treatments” Scientific Reports, Vol. 8, p. 3515 (2018)
Lau, S.K.P., Zhang, L., Luk, H.K.H., Xiong, L., Peng, X., Li, K.S.M., He, X., Zhao, P.S., Fan, R.Y.Y., Wong, A.C.P., Ahmed, S.S., Cai, J.P., Chan, J.F.W., Sun, Y., Jin, D., Chen, H., Lau, T.C.K., Kok, R.K.H., Li, W., Yuen, K.Y., Woo, P.C.Y. “Receptor Usage of a Novel Bat Lineage C Betacoronavirus Reveals Evolution of Middle East Respiratory Syndrome-Related Coronavirus Spike Proteins for Human Dipeptidyl Peptidase 4 Binding” Journal of Infectious Disease, Vol. 218, pp. 197-207 (2018)
Cheung, H.Y., Wang, F., Lau, T.C.K. “Asparagi Radix Dried at Ambient Air Temperature while Lycii Fructus at Freezing Temperature Favours the Production of its Native and Non-cohesive Fine Powder by Centrifugal-impact Pulverizer” Hong Kong Pharmaceutical Journal, Vol. 25, p. 16 (2018)
2017
Lau, S.K.P., Wong, A.C.P., Lau, T.C.K., Woo, P.C.Y. “Molecular Evolution of MERS Coronavirus: Dromedaries as a Recent Intermediate Host or Long-Time Animal Reservoir?” International Journal of Molecular Sciences, Vol. 18, E2138 (2017)
Jiang, X., Liu, X., Law, O.K., Wang, Y., Lo, W.U., Weng, X., Chan, T.F., Ho, P. L. and Lau, T.C.K. “The CTX-M-14 plasmid pHK01 encodes novel small RNAs and influences host growth and motility” FEMS Microbiology Ecology, Vol. 93, fix090 (2017)
Cheung, A.K.L., Kwok, H.Y., Huang, Y., Chen, M., Mo, Y. Wu, X., Lam, K.S., Kong, H.K., Lau, T.C.K., Zhou, J., Li, J. Cheng, L., Lee, B.K., Peng, Q., Lu, X., An, M., Wang, H., Shang, H., Zhou, B., Wu, H., Xu, A., Yuen, K.Y. and Chen, Z. “Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection” Nature Microbiology, Vol. 2, pp. 1389-1402 (2017)
Tam, K.K.G., Leung, K.S.S, To, S.W.C., Siu, G.K.H., Lau, T.C.K., Shek, V.C.M., Tse, C.W.S., Wong, S.S.Y., Ho, P.L., Yam, W.C. “Direct detection of Mycobacterium tuberculosis and drug resistance in respiratory specimen using Abbott Realtime MTB detection and RIF/INH resistance assay” Diagnostic Microbiology and Infectious Disease, Vol. 89, pp. 118-24 (2017)
Kong, H.K., Law, H.W., Liu, X., Law, C.O., Pan, Q., Gao, L., Xiong, L., Lau, S.K., Woo, P.C., Lau, T.C.K. “Transcriptomic Analysis of Laribacter hongkongensis Reveals Adaptive Response Coupled with Temperature” PLoS One, Vol. 12, e0169998 (2017)
2016
Dai, Z., Gao, Q., Cheung, M.C., Leung, H.M., Lau, T.C.K., Sleiman, H.F., Lai, K.W., Lo, P.K. “A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets.” Nanoscale, Vol. 8, pp. 18291-5 (2016)
Ye, R.R., Peterson, D.R., Seemann, F., Kitamura, S.I., Lee, J.S., Lau, T.C.K., Tsui, S.K., Au, D.W. “Immune competence assessment in marine medaka (Orzyias melastigma)-a holistic approach for immunotoxicology.” Environmental Science and Pollution Research (in press, 2016)
Zhang, X.M., Zhang, Q., Wu, H., Lau, T.C.K., Liu, X., Chu, H., Zhang, K., Zhou, J., Chen, Z., Jin, D.Y., Zheng, B.J. “Novel mutations L228I and Y232H cause NNRTI resistance in combinational pattern” AIDS Research and Human Retroviruses, Vol. 32, pp. 909-17 (2016)
2015
Lee, E.A., Lee, Sze-To, A., Wong, M.H., Leung, K.S., Lau, T.C.K., Wong, A.K.C. “Discovering Protein-DNA Binding Cores by Aligned Pattern Clustering” IEEE/ACM Transactions on Computational Biology and Bioinformatics (Epub ahead of print, 2015)
Ho, P.L., Liu, M.C., Lo, W.U., Lai, E.L., Lau, T.C.K., Law, O.K., Chow, K.H. “Prevalence and characterization of hybrid blaCTX-M among Escherichia coli isolates from livestock and other animals” Diagnostic Microbiology and Infectious Disease, Vol. 82, pp. 148-53 (2015)
Zhang, X.M., Wu, H., Zhang, Q., Lau, T.C.K., Chu, H., Chen, Z.W., Jin, D.Y., Zheng, B.J. “A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs” The Journal of Antimicrobial Chemotherapy, Vol. 70, pp. 1381-90 (2015)
2014
Li, H., Chan, C.F., Chan, W.L., Lear, S., Cobb, S.L., Mak, N.K., Lau, T.C.K., Lan, R., Wong, W.K., Wong, K.L. “Monitoring and inhibition of Plk1: amphiphilic porphyrin conjugated Plk1 specific peptides for its imaging and anti-tumor function” Organic & Biomolecular Chemistry, Vol. 12, pp. 5876-5882 (2014)
Jiang, L., Lui, Y.L., Li, H., Chan, C.F., Lan, R., Chan, W.L., Lau, T.C.K., Tsao, G.S.W., Mak, N.K., Wong, K.L. “EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells”, Chemical Communications, Vol. 50, pp. 6517-6519 (2014)
Ma, R.C., Lee, H.M., Lam, V.K., Tam, C.H., Ho, J.S., Zhao, H.L., Guan, J., Kong, A.P., Lau, E., Zhang, G., Luk, A., Wang, Y., Tsui, S.K., Chan, T.F., Hu, C., Jia, W.P., Park, K.S., Lee, H.K., Furuta, H., Nanjo, K., Tai, E.S., Ng, D.P., Tang, N.L., Woo, J., Leung, P.C., Xue, H., Wong, J., Leung, P.S., Lau, T.C.K., Tong, P.C., Xu, G., Ng, M.C., So, W.Y., Chan, J.C. “Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese”, PLoS One, Vol. 9, e84770 (2014)
Hu, X., Wong, T.K., Lu, Z.J., Chan, T.F., Lau, T.C.K., Yiu, S.M., Yip, K.Y. “Computational identification of protein binding sites on RNAs using high-throughput RNA structure-probing data”, Bioinformatics, Vol. 30, pp. 1049-1055 (2014)
2013
Ho, P.L., Chan, J., Lo, W.U., Lai, E.L., Cheung, Y.Y., Lau, T.C.K., Chow, K.H. “Prevalence and molecular epidemiology of plasmid-mediated fosfomycin resistance gene fosA3 among blood and urinary Escherichia coli isolates”, Journal of Medical Microbiology, Vol. 62, pp. 1707-1713 (2013)
Li, S.K., Zhou, J.W., Yim, A.K.Y., Leung, A.K.Y., Tsui, S.K.W., Chan, T.F., Lau, T.C.K. “Organism-specific rRNA capture system for application in Next-Generation Sequencing”, PLoS One, Vol. 8, e74286 (2013)
Li, S.K., Ng, P.K.S., Hao, Q., Lau, J.K.Y., Lau, J.P.Y., Chan, T.F., Tsui, S.K.W. and Lau, T.C.K. “Identification of small RNAs in Mycobacterium Smegmatis using heterologous Hfq”, RNA, Vol. 1, pp. 74-84 (2013)
2012
Chan, T.M.*, Leung, K.S., Lee, K.H., Wong, M.H., Lau, T.C.K.* and Tsui, S.K.W. “Subtypes of associated protein-DNA (TF-TFBS) patterns”, Nucleic Acids Research, Vol. 40, pp. 9392-9403 (2012) (*co-corresponding authors)
Zhang, J., Zhou, J.W., Chan, C.F., Lau, T.C.K.*, Kwong, D.W.J., Mak, N.K., Tam, H.L., Wong, K.L.* and Wong W.K.* “Comparative Studies of the Cellular Uptake, Subcellular Localization, Cytotoxic and Phototoxic Anti-tumor Properties of Ruthenium(II)-Porphyrin Conjugates with Different Linkers”, Bioconjugate Chemistry, Vol. 23, pp. 1623-1638 (2012) (*co-corresponding authors)
Tsoi, Ho, Lau, T.C.K., Tsang, F., Lau, K.F. and Chan, H.Y.E. “CAG expansion induces nucleolar stress in polyglutamine diseases”, Proceedings of National Academy of Sciences, Vol. 109, pp. 13428-13433 (2012)
Kang, Y., Wu, Z., Lau, T.C.K., Lu, X., Liu, L., Cheung, A.K., Tan, Z., Ng, J., Liang, J., Wang, H., Li, S.K., Zheng, B., Li, B., Chen, L. and Chen, Z. “CCR5 antagonist TD-0680 uses a novel mechanism for enhanced potency against HIV-1 entry, cell-mediated infection and a resistant variant”, Journal of Biological Chemistry Vol. 287, pp. 16499-16509 (2012)
Chan, M.C.W., Lee, N., Ho, W.S., Law, C.O.K., Lau, T.C.K., Tsui, S.K.W. and Sung, J.J.Y. “Co-variation of Major and Minor Viral Capsid Proteins in Norovirus Genogroup II Genotype 4 Strains”, Journal of Virology, Vol. 86, pp. 1227-1232 (2012)
Lu, X., Liu, L., Zhang, X., Lau, T.C.K., Tsui, S.K.W., Kang, Y., Zheng, P., Liu, G. and Chen, Z. “F18, a novel small molecule NNRTI, inhibits HIV-1 replication using distinct binding motifs”, Antimicrobial Agents and Chemotherapy, Vol. 56, pp. 341-351 (2012)
2011
Li, M.S.*, Lau, T.C.K.*, Chan, S.K.P., Wong, C.H., Ng, P.K.S., Sung, J.J.Y., Chan, H.L.Y., Tsui, S.K.W. “G1613A Mutation on HBV Core Promoter Suppresses e Antigen Secretion and Enhances Viral Replication”, PLoS One, Vol. 6, pp. e21856 (2011) (*co-authors)
Tsoi, H., Lau, C.K., Lau, K.F. and Chan, H.Y.E. “Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ disease”, Human Molecular Genetics, Vol. 20, pp. 3787-3797 (2011)
Kong, H.K., Chadbourne, F.L., Law, G.L., Li, H., Tam, H.L., Cobb, S.L., Lau, C.K.*, Lee, C.S.*, Wong, K.L.* “Responsive Two-Photon Induced f-f Emissive Detection for Cyclin A with Europium-Chelating Peptide”, Chemical Communications, Vol. 47, pp. 8052-8054 (2011) (*co-corresponding authors)
Fung, Y.O., Wu, W., Yeung, C.T., Kong, H.K., Wong, K.K.C., Lo, S.W.S., Law, G.L., Wong, K.L., Lau, T.C.K., Lee, C.S., Wong, W.T. “Responsive Dimeric Lanthanide DO3A Complex for Protein Staining and In-Vitro Imaging”, Inorganic Chemistry, Vol. 50, pp. 5517-5525 (2011)
Siu, G.K.H., Zhang, Y., Lau, T.C.K., Lau, R.W.T., Ho, P.L., Yew, W.W., Tsui, S.K.W., Cheng, V.C.C., Yuen, K.Y. and Yam, W.C. “Novel mutations outside rifampicin resistance determining region associated with rifampicin resistance in Mycobacterium tuberculosis”, The Journal of Antimicrobial Chemotherapy, Vol. 66, pp. 730-733 (2011)
2010
Lau, C.K., Hui, J., Fong, F.N.Y., To, K.T., Fok, T.F., Tang, N.L.S., Tsui, S.K.W. “Novel mutations in PHKA2 gene in glycogen storage disease type IX patients from Hong Kong, China” Molecular Genetics and Metabolism, Vol. 102, pp. 222-225 (2010)
Chan, T.M., Wong, K.C., Lee, K.H., Wong, M.H., Lau, C.K., Tsui, S.K.W., Leung, K.S. “Discovering approximate associated sequence patterns for protein-DNA interactions”, Bioinformatics, Vol. 27, pp. 471-478 (2011)
Lau, R.W.T., Ho, P.L., Kao, R.Y.T., Yew, W.W., Lau, T.C.K., Cheng, V.C.C., Yuen, K.Y., Tsui, S.K.W., Chen, X. and Yam, W.C. “Molecular Characterization of Fluoroquinolone Resistance in Mycobacterium tuberculosis: Functional Analysis of DNA Gyrase Harboring Mutation at Position 74 of gyrA”, Antimicrobial Agents and Chemotherapy, Vol. 55, pp. 608-614 (2010)
Leung, K.S., Wong, K.C., Chan, T.M., Wong, M.H. Lee, K.H., Lau, C.K., Tsui, S.K.W. “Discovering Protein-DNA binding sequence patterns using association rule mining”, Nucleic Acids Research, Vol. 38, pp. 6324-6337 (2010)
Before 2010
Sabin, L. R., Zhou, R., Gruber, J.J., Lukinova, N., Bambina, S., Berman, A., Lau, C.K., Thompson, C.B. and Cherry, S. “Ars2 regulates both miRNA- and siRNA-dependent silencing and suppresses RNA virus infection in Drosophila”, Cell, Vol. 138, pp. 340-351 (2009)
Gruber, J.J., Zatechka, D.S., Sabin, L.R., Yong, J., Lum, J.J., Kong, M., Zong, W.X., Zhang, Z., Lau, C.K., Rawlings, J., Cherry, S., Ihle, J.N., Dreyfuss, G., Thompson, C.B. “Ars2 links the nuclear cap binding complex to RNA interference and cell proliferation”, Cell, Vol. 138, pp. 328-339 (2009)
Lau, C.K., Bachorik, J. and Dreyfuss, G. “Gemin5-snRNA interaction reveals a novel RNA-binding function for WD-repeat domains”, Nature Structural and Molecular Biology, Vol. 16, pp. 486-491 (2009)
Battle, D.J., Lau, C.K., Wan, L. and Dreyfuss, G. “The Gemin5 protein of the SMN complex identifies snRNAs”, Molecular Cell, Vol. 23, pp. 273-279 (2006)
Ghosh, K., Lau, C.K., Gupta, K., and Van Duyne, G.D. “Preferential synapsis of loxP sites drives ordered strand exchange in Cre-loxP site-specific recombination”, Nature Chemical Biology, Vol. 1, pp. 275-282 (2005)
Ghosh, K., Lau, C.K., Guo, F., Segall, A., and Van Duyne, G.D. “Peptide trapping of the Holliday junction intermediate in Cre-loxP site-specific recombination”, Journal of Biological Chemistry, Vol. 280, pp. 8290-8299 (2005)
Lau, C.K., Diem M.D., Dreyfuss, G., Van Duyne, G.D. “Structure of the Y14-magoh core of the Exon junction complex”, Current Biology, Vol. 13, pp.933-941 (2003)
Li, M.H., Kwok, F., Chang, W.R., Lau, C.K., Zhang, J.P., Lo, S.C.L., Jiang, T., Liang, D.C. “Crystal structure of brain pyridoxal kinase, a novel member of the ribokinase superfamily” Journal of Biological Chemistry, Vol. 277, pp. 46385-46390 (2002)
Li, M.H., Kwok, F., An, X.M., Chang, W.R., Lau, C.K., Zhang, J.P., Liu, S.Q., Leung, Y.C., Jiang, T., Liang, D.C. “Crystallization and preliminary crystallographic studies of pyridoxal kinase from sheep brain” Acta Crystallographica Section D-Biological Crystallography, Vol. 58, pp. 1479-1481 (2002)
Lau, C.K. and Churchich, J.E. “Binding of polylysine to GroEL: Inhibition of the refolding of mitochondrial malate dehydrogenase”, Biochimica Et Biophysica Acta, Protein Structure and Molecular Enzymology, Vol. 1431, pp. 282-289 (1999)
Lau, C.K., Lo, S.C.L., Kwok, F., Churchich, D., and Churchich, J.E. “Partially-folded conformations of inositol monophosphatase endowed with catalytic activity”, Journal of Protein Chemistry, Vol. 17, pp. 789-797 (1998)
Gao, Z.G., Lau, C.K., Lo, S.C.L., Churchich, J.E. and Kwok, F. “Porcine pyridoxal kinase. cDNA cloning, expression and primary sequence confirmation”, The International Journal Of Biochemistry and Cell Biology, Vol. 30, pp. 1379-1388 (1998)
Lau, C.K., Wong, R.N.S., Lo, S.C.L., and Kwok, F. “Refolding of denatured trichosanthin in the presence of GroEL”, Biochemical and Biophysical Research Communication, Vol. 245, pp. 149-154 (1998)